Macrophage polarization and adiponectin 1 MOLECULAR MECHANISM FOR ADIPONECTIN-DEPENDENT M2 MACROPHAGE POLARIZATION: LINK BETWEEN THE METABOLIC AND INNATE IMMUNE ACTIVITY OF FULL-LENGTH ADIPONECTIN
نویسندگان
چکیده
Departments of Pathobiology and Gastroenterology, Cleveland Clinic, Cleveland, OH 44195 and Department of Molecular Medicine, Case Western Reserve University, Cleveland OH 44120 Running title: Macrophage polarization and adiponectin Address correspondence to: Palash Mandal, Cleveland Clinic Foundation, Lerner Research Institute/NE-40 9500 Euclid Avenue, Cleveland, OH 44195, Phone 216-444-4021 FAX: 216-636-1493, [email protected]
منابع مشابه
Molecular mechanism for adiponectin-dependent M2 macrophage polarization: link between the metabolic and innate immune activity of full-length adiponectin.
The anti-inflammatory effects of globular adiponectin (gAcrp) are mediated by IL-10/heme oxygenase 1 (HO-1)-dependent pathways. Although full-length (flAcrp) adiponectin also suppresses LPS-induced pro-inflammatory signaling, its signaling mechanisms are not yet understood. The aim of this study was to examine the differential mechanisms by which gAcrp and flAcrp suppress pro-inflammatory signa...
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